Treatment for Immune system dysfunctions and abnormalities:
- Treatment for chronic inflammatory immune response to molds, mycobacteria and mycotoxins
- GC-MAF treatment
- Treatment for abnormalities in the 2-5a synthetase / RnaseL anti-viral pathway & PKR pathway
- Treatments to balance and normalise Cytokines, normalise the cell numbers and functions of the following - NK cells, T-cells, Lymphocytes, B-cells, CD8+ cells, Macrophages and other Immune cell subsets, complement factor and Cell Mediated Immunity
- Treatment for Microbiome and Intestines (75% of all immune system cells)
- Treatment for Autoimmune disorders (including B cell abnormality and Autoimmune marker mimcry)
- Treatment for Vitamin D deficiency
- Treatment for Methylation Blockage
- Treatment for adverse immune reactions to vaccines
- Reduction of toxins and Inflammation agents in the diet and body
- Lymphatic Drainage and Detoxification (Including Perrin Technique)
- Other Immune Dysfunctions Treatments

 

Important Note
If tests show that you suffer from any of these abnormalities and dysfunctions, you can view the treatment options available and discuss them with your own medical doctor or consultant. These treatments can only be undertaken with the permission and supervision of your own medical doctor


1. Treatment for chronic inflammatory immune response to molds and mycotoxins

One study found that 93% of ME patients had mycotoxin exposure, with many having multiple mycotoxin exposures, while none of the healthy controls had evidence of mycotoxin exposure. Mycotoxin exposure has been proven to lead to immune activation, in particular a chronic inflammatory state, and to endocrine system and nervous system abnormalities all which are consistently found in ME patients. Dr. Paul Cheney, Dr. De Meirleir and Dr. Peterson are now using tests for mycotoxins as part of their diagnostics protocol for ME / CFS. See Section - Treatment for chronic inflammatory immune response to molds and mycotoxins

 

2. Treatment of all chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections
Diagnose, treat and eliminate chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections which both activate and weaken the immune system over time. This is essential in all cases of ME and CFS. Immune pathways and signalling systems can be disrupted by chronic infections. B cells are prone to infections which can instigate immune dysfunctions and autoimmune conditions and dispersal of infections to the liver, spleen, kidneys, nervous system, etc.


3. Normalise GcMAF levels and eliminate Nagalase

 

4. Treatment for abnormalities in the 2-5a synthetase / RnaseL anti-viral pathway & PKR pathway

  • Treatment of all chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections
    Diagnose, treat and eliminate chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections which both activate and weaken the immune system over time. This is essential in all cases of ME and CFS. Immune pathways and signalling systems can be disrupted by chronic infections. B cells are prone to infections which can instigate immune dysfunctions and autoimmune conditions.
  • Ampligen   produced by Hemispherx Biopharma, Inc   http://www.hemispherx.net
     Ampligen has strong immuno-modulatory properties, anti-viral activity against RNA and DNA viruses, and anti-tumour cell properties. Ampligen has proved effective in some ME subgroups. Dr. De Meirleir has stated that 80% of his patients experienced clinical recovery from Ampligen and Dr. Lapp has found it very effective in 50% of cases. It is approved for ME, CFS and AIDS treatment in Canada and Belgium and in open trial cases in some medical practises in the USA.
    Research articles         
    -      http://www.hemispherx.net/content/rnd/abstract_scientfic.htm
    - Changes in the 2-5A synthetase/ RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. Suhadolnik RJ , Reichenbach NL , Hitzges P , Adelson ME , Peterson DL , Cheney P , Salvato P , Thompson C , Loveless M , Müller WE , et al. In Vivo. 1994 Jul-Aug;8(4):599-604. PMID: 7893988
    - A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonistrintatolimod in severe cases of chronic fatigue syndrome. Strayer DR , Carter WA , Stouch BC , Stevens SR , Bateman L , Cimoch PJ , Lapp CW , Peterson DL ; Chronic Fatigue Syndrome AMP-516 Study Group , Mitchell WM . . PLoS One. 2012;7(3):e31334. PMID: 22431963
    -  http://www.hemispherx.net/content/rnd/drug_candidates.htm
    -  What is Ampligen ?
    - Chronic Fatigue Syndrome: A Biological Approach by Patrick Englebienne and Dr. Kenny De Meirleir 
    - Dr. De Meirleir has had some success with Ampligen combined anti-pathogen therapy in his clinic in Belgium. Dr. De Meirlier claims that an eight-year follow-up of patients treated successfully with Ampligen found that 92% had not relapsed.
    - Ampligen by itself may be limited in it's effects, but combining it with anti-viral and anti-pathogen treatments may bring about better improvement and a high probability of full recovey. Some ME clinics use this. See listing of clinics in Diagnosis and Treatments section
    - HHV-6a's growth is stopped by the experimental drug Ampligen. Ablashi, D.V. et al.; Ampligen Inhibits In Vitro Replication of HHV-6"; Abstract from CFS conference, Albany, NY, October 2-4, 1992
    When HHV-6a virus growth is stopped by the experimental drug Ampligen in Chronic Fatigue Syndrome patients, their symptoms resolve. (In a trial published in 1987, the same appeared to be true for "AIDS" patients treated with Ampligen.) Strayer, D.R. et al.; "A Controlled Clinical Trial With a Specifically Configured RNA Drug, Poly(I):Poly(C12U), in Chronic Fatigue Syndrome";Clinical Infectious Diseases, January 1994.
    Combining anti-pathogen medicine with Immune system modulators and enhancers can bring about strong and sustained recovery over time.

  • Elastase inhibitors
    Human leukocyte elastase inhibitors to treat patients with ME/CFS. This helps normalise the RnaseL and PKR and STAT1 mechanisms in ME/CFS patients.     And prevents ion channel interruption and dysfunctions.
    - Alpha-1-Antitrypsin. Strong anti-elastase activity and also activates gene expression for normalising RnaseL activity. It reduces an important inflammation marker and inflammatory cytokines. It also encourages natural production of Alpha-1-Antitrypsin by the body.
    The Use of Alpha-1-Antitrypsin for the Treatment of Chronic Fatigue Syndrome Garcia, Quintana et al.
    - Boswellia  (Boswellic acid). Strong anti-elastase activity. A herb used in many countries.
    - Cefoperazone  (Pfizer Pharmaceuticals, trade name Cefobid)  -  Dr. Kenny De Meirleir has shown that it can block the elastase activity which is involved in destroying the immune systems of ME/CFS patients
    - Beta-lactam based antibiotics act as leukocyte elastase inhibitors
    -     Research articles & Clinical Findings 
    - Total Exposure - Expanded Model for RNase L Fragmentation in CFS Uncovered; The National CFIDS Foundation Announces the Use of Elastase Inhibitors as a Potential Treatment for CFS Patients (2003)
    - Chronic Fatigue Syndrome: A Biological Approach by Patrick Englebienne and Dr. Kenny De Meirleir 
    - The Use of Alpha-1-Antitrypsin for the Treatment of Chronic Fatigue Syndrome     Garcia, Quintana et al.
    - some ME clinics use this. See listing of clinics in Diagnosis and Treatments section

  • M-Calpain and Cathepsin-G inhibitors
    Elastase, cathepsin-G and m-calpain are responsible for fragmenting RnaseL. Medication to block cathepsin-G and m-calpain, and normalise RnaseL and PKR pathways would benefit patients.

  • Anti IFN beta
    Certain toxic chemicals and certain viruses produce the same kinds of inflammatory effects and defects in 2-5A Synthetase and Protein Kinase RNA (PKR)). Anti IFN beta inhibited the reactions.
    Vojdani A , Lapp CW . Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome. Immunopharmacol Immunotoxicol. 1999 May;21(2):175-202. PMID: 10319275
  • MG132  to stop STAT1-alpha cleavage and degradation.
    Research articles   
    -  STAT1-alpha and p53 Deficiencies are Found in Patients with Chronic Fatigue Syndrome (2003)
    - ' Chronic Fatigue Syndrome :  A Biological Approach '  by Patrick Englebienne and Dr. Kenny De Meirleir 
    - some ME clinics use this. See listing of clinics in Diagnosis and Treatments sectio

  • Acclydine Therapy recommended by Dr. De Meirleir  (top CFS doctor and researcher)
    Research articles
    - Chronic Fatigue Syndrome: A Biological Approach by Patrick Englebienne and Dr. Kenny De Meirleir 
    - some ME clinics use this. See listing of clinics in Diagnosis and Treatments section    .


  • Increasing and normalising TH1 cytokines and reducing TH2 cytokines may normalise RnaseL levels and other Immune system factors indirectly. The best herbs for reducing TH2 cytokines and increasing TH1 cytokines and NK cell numbers and activities
    • Chinese Skullcap (Scutellaria baicalensis) is the most powerful herb in this category
    • Combining the herbs Astragalus, Cordyceps, Rhodiola, Ashwagandha, Siberian Ginseng and Reishi mushrooms , according to renowned herbalist Stephen Buhner
    • Andrographis paniculata
    • Japanese Knotweed
    • Cats Claw
    • Ashwagandha
    • Turmeric
  • Olive leaf extract and olive leaf soups have broad anti-viral, anti-bacteria and anti-parasite properties. It is effective against RNA and DNA viruses. It can also modulate and restore immune system functions.
    Research articles & Clinical Findings
    - Research findings - viruses
    - Research findings - bacteria
    - Research findings - Lyme
    - Research findings - immune system

  • The Marshall Protocol
    This is designed to modulate the immune system. According to it's author and it's many supporters, it can improve one's ability to utlilise Vitamin D and this directly impacts many immune system subsets and functions, and toll receptors, it improves VDR, and it can reduce NFκB and TNF-a and inflammatory cytokines. It can also improve innate immunity and TH1 cytokines. These are major factors in ME and CFS. More information is presented here at :
    The Marshall Protocol web site and the following video lecture



  • Lactobacillus acidophilus and probiotics can increase TH1 cytokines, reduce TNF-a, reduce cytokine IL-6, reduces CRP, improve mucousal integrity and intestinal integrity, and improve overall immune system functions. Its also helpful in autoimmunity. Bifidobacterium infantis 35624 is particularly good for ME patients.
    Click here to view Probiotics & Immunity

 

5. Treatments to balance and normalise NK cells, Cytokines, T-cells, Lymphocytes, B-cells, CD8+ cells, Macrophages and other Immune cell subsets, complement factor and Cell Mediated Immunity

Treatment of all chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections
Diagnose, treat and eliminate chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections which both activate and weaken the immune system over time. This is essential in all cases of ME and CFS. Immune pathways and signalling systems can be disrupted by chronic infections. B cells are prone to infections which can instigate immune dysfunctions and autoimmune conditions.


Normalise NK cell numbers, functions and cytotoxicity

  • Basic nutritional requirements - Vitamin C (2g or greater), Co-enzyme Q10 (200mg), Omega-3 (4g). Check levels of Vitamin D3 and Vitamin B12 in the blood and tissues. (Nancy Klimas' clinic at Nova Southeastern University, Florida).
  • Medical drugs and treatments to:
    - block inhibitory KIR receptors could improve NK cell functions in ME patients.
    Wu GQ, Zhao YM, Huang H, Lai XY (2011) [Effects of blocking inhibitory KIR receptors on cytotoxic activity of human NK cells in vitro]. Zhejiang Da Xue Xue Bao Yi Xue Ban 40: 475-481
    - improve NK cell function, numbers and cytotoxicity
    - Increase perforin levels
    - Increase Granzyme B levels

  • Shiitake mushrooms & Lentinan improves NK cell function, numbers and cytotoxicity
    Lentinan by injection     is used in Japan to treat ME or "Low natural killer cell syndrome" as it is called in Japan. Lentinan is derived from Shiitake mushrooms and enhances the functions of NK cells, Macrophages and Lymphocytes. It is a powerful immune system enhancer. Shiitake mushroom can be bought in most shops.
    Research articles & Clinical Findings
    - Miyakoshi H, Aoki T, Mizukoshi: Acting mechanisms of Lentinan in humans.  II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon induced response.  Int J Immunopharmacol 6:373-379, 1984
    - Aoki T, Miyakoshi H, and Usada Y et al: Low NK syndrome and its relationship to chronic fatigue syndrome. Clin Immunol Immunopathol. 69:253-65, 1993.
    - Aoki T, Usada Y, Miyakoshi H: A novel immunodeficiency: Low NK syndrome (LNKS).  Jap J Med 3212:14-17, 1985
    - Aoki T, Usuda Y, Miyakashi H, et al: Low natural syndrome: clinical and immunologic features. Nat Immun Cell Growth Regul 6:116-128, 1987
    - Research findings concerning Shiitake mushrooms and the immune system
    - Research regarding Lentinan
    - Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Page 6
  • The best herbs for reducing TH2 cytokines and increasing TH1 cytokines and improving NK cell numbers and activities
    • Chinese Skullcap (Scutellaria baicalensis) is the most powerful herb in this category
    • Combining the herbs Astragalus, Cordyceps, Rhodiola, Ashwagandha, Siberian Ginseng and Reishi mushrooms , according to renowned herbalist Stephen Buhner
    • Andrographis paniculata
    • Japanese Knotweed
    • Cats Claw
    • Ashwagandha
    • Turmeric
  • Astragalus - very powerful immune system enhancer and modulator. It normalises and strengthens overall immunity, including NK cells, T-cells and TH1 cytokines and most immune system subsets.
    Research articles & Clinical Findings
    - Kuo YH , Tsai WJ , Loke SH , Wu TS , Chiou WF . Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol. 2009 Feb 25;122(1):28-34. PMID: 19103273
    - Research findings concerning Astragalus and the immune system
  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.
  • Colostrum contains many immune system components, antibodies, immunoglobulins, cytokines, interferons, proline-rich polypeptides, transfer factors, amino acids, growth factors, lactoferrin and vitamins to normalise immune system functions. It is a very strong immune system modulator and improves NK cell numbers and functions, T cells and TH1 cytokines when used over several months and years. There are some good Colostrum products in the market. These include Colostrinin and Travelan which have been researched. Colostrum pills / powder / milk / cheeses can be bought online and offline. Natural Colostrum has been found to be very effective.
    Research articles & Clinical Findings
    - Listing of scientific research
  • Treat Glutathione Decificency to improve NK cells numbers and functions and perforin levels
     Glutathione is essential for many immune system functions. One can take Glutathione by injection and / or take Glutathione precursors. Glutathione precursors - undenatured whey protein, Immunocal / ImuPlus, N-acetyl cysteine (NAC), selenium, Alpha-lipoic acid, carnitine, cruciferous vegetables, vitamin c, glutamine, milk thistle, green barley grass, copper, manganese, zinc. Vitamin B-complex is important for Glutathione production. Also test your methylation cycle, and correct any problems or blocks ; Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment
    Research articles & Clinical Findings
    - Research findings concerning Glutathione and the immune system
    - Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.
  • Equilibriant can modulate the immune system and improve NK cell numbers and function
    Research articles & Clinical Findings
    - Dr. Chia has had some success with this supplement. See article

  • Melatonin can improve NK cell numbers and function, and reduce inflammation and fatigue.
    Research articles & Clinical Findings
    Research papers
  • Neem promotes IFN-gamma and increases CD8s. Neem is strong promoter of TH-1 cytokine responses (IL-12, IL-2 and IFN-gamma) also, a powerful antiviral, antifungal and antibacterial herb.
    Research articles & Clinical Findings
    - Research findings concerning Neem and the immune system

  • Glatiramer acetate can improve NK cell functions
    - Arnon, R., Aharoni, R. 2009. Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate. Journal of Neural Transmission. 116, 1443-1449.
    - Schrempf, W. and Ziemssen, T. Glatiramer acetate: mechanisms of action in multiple sclerosis. Autoimmunity Reviews. 6, 469-475.

  • Carnivora and Carnivora extract modulates the immune system, helps normalise cytokines, NK cells, CD8 T cells and interferons and overall immune functions. Target viruses and pathogens.
    Research articles & Clinical Findings 
    -     Listing of scientific research
  • Larix or Larch is a strong immune system stimulant, and can increase NK cell numbers and cytotoxicity. It also improves macrophages, TH1 cytokines and cell mediated immunity.
    Research articles & Clinical Findings
    Scientific Research
  • Ginseng can increase TH1 cytokines and activity, t-cells and nk cells, and improve overall immune system function
    Research articles     & Clinical Findings
    - See DM , Broumand N , Sahl L , Tilles JG . In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology. 1997 Jan;35(3):229-35. PMID: 9043936
    - Bentler SE , Hartz AJ , Kuhn EM . Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625-32. PMID: 15889950
    - Research findings concerning Ginseng and the immune system

  • Pine Cone Extract Dr. Cheney believes it strengthens the TH1 part of the immune system, and enhances overall immune function. Research suggests that it has beneficial effects on the entire immune system.
    Research articles & Clinical Findings
    - Scientific papers
  • BioPro Protein A - Thymus gland strenghtening. This is vital for all immune system subsets and functions.
    Research articles & Clinical Findings
    - Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Pages 113.- 115

  • Combining Scutellaria baicalensis (chinese skullcap) and Japanese knotweed can increase NK cell activities and functions and improve TH1 immune response
  • Lycopene. Found in tomatoes and tomato sauces and Lycopene supplements. Improves natural killer cell activity
    Research articles & Clinical Findings
    - Proc Nutr Soc. 1998; 57: 3A
    - Scientific findings

  • Lactobacillus acidophilus and probiotics can increase TH1 cytokines, reduce TNF-a, reduce cytokine IL-6, reduces CRP, improve mucousal integrity and intestinal integrity, and improve overall immune system functions. Its also helpful in autoimmunity. Bifidobacterium infantis 35624 is particularly good for ME patients.
    Click here to view Probiotics & Immunity
  • Green Tea should not be taken by ME and CFS patients as it increases TH2 inflammatory cytokines
  • Noni is an immune system modulator. It can increase macrophages and TH1 cytokines.
    Research articles & Clinical Findings
    Scientific Research

  • Cat's Claw is a strong immune system modulator. It can increase NK cell activity and balances TH1 and TH2 cytokines and reduces inflammation, and increases the immune system's ability to fight viruses and bacteria.
    Research articles & Clinical Findings
    - Scientific papers
  • Echinacea is an immune stimulant and modulator. It can improve NK cell function and T cells and the body's ability to fight infections.
    Research articles & Clinical Findings
    - See DM , Broumand N , Sahl L , Tilles JG . In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology. 1997 Jan;35(3):229-35. PMID: 9043936
    - Research Findings

  • Siberian Ginseng can increase white blood cells, t-cell and natural killer cell functions and overall immunity
    Research articles & Clinical Findings
    - Research findings concerning Siberian Ginseng and the immune system
  • Natural Killer cell functions and numbers Dr. Edward Conley of the Fatigue, Fibromyalgia and Autoimmune Clinic, Michigan, USA has information about new treatments for natural killer cells, which are proving successful in his clinic.

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines, molecular parts) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.

Anti-pathogen treatments which can modulate and help normalise the immune system

  • Staphylococcal toxoid vaccine / Staphypan Berna vaccine have proved effective in improving and normalising the immune system in many cases. Recoveries have occurred in over 50% of cases.
    Research articles & Clinical Findings
    - Andersson, M; Bagby, JR; Dyrehag, L; Gottfries, C (1998). "Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome". European journal of pain (London, England) 2 (2): 133–142. doi:10.1016/S1090-3801(98)90006-4
    - Zachrisson O , Regland B , Jahreskog M , Jonsson M , Kron M , Gottfries CG . Treatment with staphylococcus toxoid in fibromyalgia/chronic fatigue syndrome--a randomised controlled trial. Eur J Pain. 2002;6(6):455-66. PMID:12413434
    - Zachrisson O , Colque-Navarro P , Gottfries CG , Regland B , Möllby R . Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement. Eur J Clin Microbiol Infect Dis. 2004 Feb;23(2):98-105. PMID: 14735403
  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.
  • Oxygen Therapy and UVB Therapy - very strong anti-viral, anti-bacterial, anti-mycoplasma and anti-parasite effects.
    • Ultra Violet Irradiation therapy (UVB) has been found to be very effective in ME and in other chronic and infectious illnesses. This is used reguarly in the famous Biocare Hospital in Mexico, which caters for international business people and professionals. This treatment may be available in your country.
    • Oxygen therapy, Hyperbaric Oxygen Therapy (HBOT) are strongly anti-microbial and can be effective in many cases. This is used reguarly in the famous Biocare Hospital in Mexico.
    • Ozone therapy and hydrogen peroxide therapy are strongly anti-microbial and can be effective in some cases. This is used reguarly in the famous Biocare Hospital in Mexico.
    • Photo-ox therapy has been found to be very effective in eliminating pathogens from the body by Dr. Steven Bock. www.rhinebeckhealth.com
      Research
      - The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome. Akarsu S , Tekin L , Ay H , Carli AB , To k F , Sim s ek K , Kiralp MZ . Undersea Hyperb Med. 2013 Mar-Apr;40(2):197-200. PMID: 23682549
  • Carnivora and Carnivora extract modulates the immune system, helps normalise cytokines, NK cells, CD8 T cells and interferons and overall immune functions. Target viruses and pathogens.
    Research articles & Clinical Findings 
    -     Listing of scientific research

 

Normalise CD8 T cells

  • Carnivora and Carnivora extract modulates the immune system, helps normalise cytokines, NK cells, CD8 T cells and interferons and overall immune functions. Target viruses and pathogens.
    Research articles & Clinical Findings 
    -     Listing of scientific research

  • Isoprinosine (Immunovir) to strengthen the TH1 part of the immune system, and T-cells, NK cells and CD8 T cells of immune system. Highly recommended by Dr. Paul Cheney (Dr. Paul Cheney has successfully treated hundreds of CFS patients in . Dr. Nancy Klimas has reported an 85% postive response rate with Isoprinosine.
    Research articles & Clinical Findings
    - Lecture given by Dr. Paul Cheney
    - Research findings concerning Isoprinosine and the immune system
    - Research Articles in Phoenix Rising
    - some ME clinics use this. See listing of clinics in Diagnosis and Treatments section

  • The best herbs for reducing TH2 cytokines and increasing TH1 cytokines & improving CD8 T cell numbers and functions
    • Chinese Skullcap (Scutellaria baicalensis) is the most powerful herb in this category
    • Combining the herbs Astragalus, Cordyceps, Rhodiola, Ashwagandha, Siberian Ginseng and Reishi mushrooms , according to renowned herbalist Stephen Buhner
    • Andrographis paniculata
    • Japanese Knotweed
    • Cats Claw
    • Ashwagandha
    • Turmeric

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.

  • Neem promotes IFN-gamma and increases CD8s. Neem is strong promoter of TH-1 cytokine responses (IL-12, IL-2 and IFN-gamma) also, a powerful antiviral, antifungal and antibacterial herb.
    Research articles & Clinical Findings
    - Research findings concerning Neem and the immune system

  • Vitamin D and medical drugs to improve CD8 T cell numbers and function
    Pender MP (2012), CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis , Autoimmune Dis, PMID: 22312480

  • BioPro Protein A - Thymus gland strenghtening. This is vital for all immune system subsets and functions.
    Research articles & Clinical Findings
    - Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Pages 113.- 115

  • Olive leaf extract and olive leaf soups have broad anti-viral, anti-bacteria and anti-parasite properties and help modulate and restore immune system functions.
    Research articles & Clinical Findings
    - Research findings - viruses
    - Research findings - bacteria

  • Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment

  • Treat Glutathione Decificency
     Glutathione is essential for many immune system functions. One can take Glutathione by injection and / or take Glutathione precursors. Glutathione precursors - undenatured whey protein, Immunocal / ImuPlus, N-acetyl cysteine (NAC), selenium, Alpha-lipoic acid, carnitine, cruciferous vegetables, vitamin c, glutamine, milk thistle, green barley grass, copper, manganese, zinc. Vitamin B-complex is important for Glutathione production. Also test your methylation cycle, and correct any problems or blocks ; Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment

    Research articles & Clinical Findings
    - Research findings concerning Glutathione and the immune system
    - Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.

  • Green Tea should not be taken by ME and CFS patients as it increases TH2 inflammatory cytokines

  • Lactobacillus acidophilus and probiotics can increase TH1 cytokines, reduce TNF-a, reduce cytokine IL-6, reduces CRP, improve mucousal integrity and intestinal integrity, and improve overall immune system functions. Its also helpful in autoimmunity. Bifidobacterium infantis 35624 is particularly good for ME patients.
    Click here to view Probiotics & Immunity

  • Astragalus - very powerful immune system enhancer and modulator. It normalises and strengthens overall immunity, including NK cells, T-cells and TH1 cytokines and most immune system subsets.
    Research articles & Clinical Findings
    - Kuo YH , Tsai WJ , Loke SH , Wu TS , Chiou WF . Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol. 2009 Feb 25;122(1):28-34. PMID: 19103273
    - Research findings concerning Astragalus and the immune system

  • Echinacea is an immune stimulant and modulator. It can improve NK cell function and T cells and the body's ability to fight infections.
    Research articles & Clinical Findings
    - See DM , Broumand N , Sahl L , Tilles JG . In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology. 1997 Jan;35(3):229-35. PMID: 9043936
    - Research Findings

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines, molecular parts) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.

  • Propax NT Factor improves overall immune system functions and protects ATP and cell membranes. It has been researched in clinical trials.
    Clinical and scientific research data
    - See web site Propax NT Factor
    - Lipid Replacement Therapy Drink Containing a Glycophospholipid Formulation Rapidly and Significantly Reduces Fatigue While Improving Energy and Mental Clarity, by R. Ellithorpe, R. Settineri, C. Mitchell, B. Jacques, E. Ellithorpe, and G. L. Nicolson, Functional Foods in Health and Disease, 2011; 8: 245-254
    - Metabolic Syndrome and Mitochondrial Function: Molecular Replacement and Antioxidant Supplements to Prevent Membrane Peroxidation and Restore Mitochondrial Function, Garth L. Nicolson, Journal of Cellular Biochemistry 2007; 100: 1352-1359.
    - Scientific research listing at http://www.immed.org/fatigue_illness_research.html
    - Scientific Review of NT Factor

  • Fetal cell extracts (Live Cell Therapy) modulates the immune system and acts to normalise immune system functions
    Research articles & Clinical Findings
    - Clinical findings by medical doctors at famous Biocare Hospital in Mexico.

  • Gene-based therapies. According to recent genetic research by Dr. Kerr (1) there are 7 subgroups of ME and certain drugs may be beneficial for CFS subgroups. These are listed below:
    • APP gene. Drug: AAB-001. Subtypes 1, 2, 3, 4, 5, 6 and 7
    • CXCR4 gene. Drug: JM1300. Subtypes 5 and 6
    • FNTA gene. Drug: lonafarnib, tipifarnib. Subtypes 1, 2, 3, 5 and 6
    • IL6ST gene. Drug: tocilizumab. Subtypes 1, 2, 5, 6 and 7
    • TNF gene. Drug: golimumab, adalimumab, etanercept, certolizumab pegol, infliximab. Subtype 2

    Research articles & Clinical Findings
    1. Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr, B Burke, R Petty, J Gough, D Fear, D L Mattey, J S Axford, A G Dalgleish, D J Nutt. J. Clin. Pathol. 2008;61;730-739; originally published online 5 Dec 2007

  • Rectify Mitochondria dysfunctions. The mitochondria are essential to many immune system functions
    Research articles & Clinical Findings
    - Treatments for damaged Mitochondria anddefective Krebs cycle and ATP production

  • Normalise the HPA axis and endocrine system. This facilitates normal immune system function. HPA axis and Thyroid and Adrenal glands dysfunction tests (Found in high percentage of CFS cases)

 

Cytokines. Medications to block inflammatory cytokines, and normalise cytokines and Leptin levels

  • Specific anti inflammatory TH2 cytokine medications. This will depend on diagnostic tests and which particular inflammatory cytokines are overactive and the reasons for their overactivity, such as infections, parasites, autoimmunity, allergic reactions, molds / mycotoxins or chemical / heavy metal toxins. Obviously treatment and elimination of infections will take precedence.

  • The best herbs for reducing TH2 cytokines and increasing TH1 cytokines and NK cell numbers and activities
    • Chinese Skullcap (Scutellaria baicalensis) is the most powerful herb in this category
    • Combining the herbs Astragalus, Cordyceps, Rhodiola, Ashwagandha, Siberian Ginseng and Reishi mushrooms , according to renowned herbalist Stephen Buhner
    • Andrographis paniculata
    • Japanese Knotweed
    • Cats Claw
    • Ashwagandha
    • Turmeric

  • Specific anti inflammatory TH2 cytokine herbs. The Buhner Protocols in Healing Lyme and Co-infections by Buhner (2015) page 212

  • IL-10 inhibitor helps increase TH1 cytokines and destroy infections. The Buhner Protocols in Healing Lyme and Co-infections by Buhner (2015) page 212

  • Zadaxin is a new drug which specifically increases TH1 cytokines and enhances immune system function. Clinical findings for ME have been excellent. This drug is undergoing research trials for it's application in ME and other diseases involving immune system disorders. It is available on prescription

  • TNF-a blocker medication. Enbrel and Adalimumab (Humira) infliximab (Remicade),  certolizumab pegol (Cimzia), and golimumab(Simponi), pentoxifylline and bupropion. These class of drugs reduce the high levels commonly found in ME patients. Turmeric (curcumin), medicinal cannabis, and Echinacea purporea have strong anti-TNF effects.

  • Anti-COX2 medication. Also Acai berries can inhibit COX1 and COX2. Turmeric is COX2 inhibitor.

  • Anti-NFκB medication. Also Turmeric and Japanese Knotweed and Uncaria rhynchophylla are powerful NFκB inhibitors
  • Leptin modulator medication

  • Monoclonal antibody drugs

  • Glatiramer acetate can reduce inflammatory cytokines
    - Arnon, R., Aharoni, R. 2009. Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate. Journal of Neural Transmission. 116, 1443-1449.
    - Schrempf, W. and Ziemssen, T. Glatiramer acetate: mechanisms of action in multiple sclerosis. Autoimmunity Reviews. 6, 469-475.
  • Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment

  • Omega-3 oil and Evening Primrose oil can reduce inflammatory cytokines and improve overall immunity. Its also helpful in autoimmunity.
    Research articles & Clinical Finding
    - Research findings concerning Omega-3 oils and the immune system
    - Research on Evening Primrose oil

  • Turmeric reduces inflammatory cytokines and enhances overall immunity.
    Research articles & Clinical Finding
    - Gupta A , Vij G , Sharma S , Tirkey N , Rishi P , Chopra K . Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model. Immunobiology. 2009;214(1):33-9. PMID: 19159825
    - Research findings concerning Turmeric and the immune system
  • Neem promotes IFN-gamma and increases CD8s. Neem is strong promoter of TH-1 cytokine responses (IL-12, IL-2 and IFN-gamma) also, a powerful antiviral, antifungal and antibacterial herb.
    Research articles & Clinical Finding
    - Research findings concerning Neem and the immune system

  • Carnivora and Carnivora extract modulates the immune system, helps normalise cytokines, NK cells, CD8 T cells and interferons and overall immune functions. Target viruses and pathogens. The elimination of pathogens helps balance and normalise the cytokines.
    Research articles & Clinical Findings 
    -     Listing of scientific research

  • Olive leaf extract and olive leaf soups have broad anti-viral, anti-bacteria and anti-parasite properties and help modulate and restore immune system functions. The elimination of pathogens helps balance and normalise the cytokines.
    Research articles & Clinical Findings
    - Research findings - viruses
    - Research findings - bacteria
    - Research findings - Lyme
    - Research findings - immune system

  • Elagen is a powerful adaptogen and immune system tonic and enhancer. Many ME patients have benefitted from taking it.
    Research articles & Clinical Findings
    - http://www.elagen.com/research/
    - Patient Testimonials

  • Kuibitang (KBT) drug regulates cytokines
    Shin HY , An NH , Cha YJ , Shin EJ , Shin TY , Baek SH , Kim CH , Lyu YS , Lee EJ , Kim HM . Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients. J Ethnopharmacol. 2004 Feb;90(2-3):253-9. PMID: 15013189

  • bojungikki-tang (Chinese) inhibits several inflammatory cytokines and markers.
    Shin HY , Shin CH , Shin TY , Lee EJ , Kim HM . Effect of bojungikki-tang on lipopolysaccharide-induced cytokine production from peripheral blood mononuclear cells of chronic fatigue syndrome patients. Immunopharmacol Immunotoxicol. 2003 Nov;25(4):491-501. PMID: 14686792
  • Low Dose Naltrexone. This can improve NK cell function, reduce B-cells, and reduce microglial cell activity, and improve overall immune system function. It also regulates endorphins which affects immune system functions according to the findings of Dr. Bihari. It is used in some autoimmune diseases. Dr. Klimas has had some success with it in treating Fibromyalgia.
    Research articles & Clinical Findings
    - Research Articles in Phoenix Rising
    - Fibromyalgia Symptoms are reduced by low-dose naltrexone: A pilot study. Pain Medicine (2009). Jarred W. Younger and Sean C. Mackey
    - Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Younger J, Noor N, McCue R, Mackey S. Arthritis Rheum. 2013 Feb;65(2):529-38.
    - Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome. Conti F, Pittoni V, Sacerdote P, Priori R, Meroni PL, Valesini G. Clin Exp Rheumatol. 1998 Nov-Dec;16(6):729-32.
    - Research findings concerning Naltrexone and the immune system
    - http://www.lowdosenaltrexone.org
    - some ME clinics use this. See listing of clinics in Diagnosis and Treatments section

  • Astragalus - very powerful immune system enhancer and modulator. It normalises and strengthens overall immunity, including NK cells, T-cells and cytokines and most immune system subsets.
    Research articles & Clinical Findings
    - Kuo YH , Tsai WJ , Loke SH , Wu TS , Chiou WF . Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. J Ethnopharmacol. 2009 Feb 25;122(1):28-34. PMID: 19103273
    - Research findings concerning Astragalus and the immune system
  • Treat Glutathione Decificency
     Glutathione is essential for many immune system functions. One can take Glutathione by injection and / or take Glutathione precursors. Glutathione precursors - undenatured whey protein, Immunocal / ImuPlus, N-acetyl cysteine (NAC), selenium, Alpha-lipoic acid, carnitine, cruciferous vegetables, vitamin c, glutamine, milk thistle, green barley grass, copper, manganese, zinc. Vitamin B-complex is important for Glutathione production. Also test your methylation cycle, and correct any problems or blocks ; Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment
    Research articles & Clinical Findings
    - Research findings concerning Glutathione and the immune system
    - Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.
  • Noni is an immune system modulator. It can increase macrophages and TH1 cytokines.
    Research articles & Clinical Findings
    Scientific Research

  • Cat's Claw is a strong immune system modulator. It balances TH1 and TH2 cytokines and reduces inflammation, and increases the immune system's ability to fight viruses and bacteria.
    Research articles & Clinical Findings
    - Scientific papers

  • Ginseng can increase TH1 cytokines and activity, t-cells and nk cells, and improve overall immune system function
    Research articles     & Clinical Findings
    - See DM , Broumand N , Sahl L , Tilles JG . In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology. 1997 Jan;35(3):229-35. PMID: 9043936
    - Bentler SE , Hartz AJ , Kuhn EM . Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625-32. PMID: 15889950
    - Research findings concerning Ginseng and the immune system

  • Ashwagandha can improve overall immunity and TH1 cytokines, and endocrine and neurological functions, all of which are impaired in ME patients.
    Research articles & Clinical Findings
    - Research findings concerning Ashwagandha and the immune system

  • Soil Based Organisms - destroy most viruses, bacteria and pathogens and can shift the immune system from inflammatory TH2 to TH1, and strongly improves immune system function
    Research articles     & Clinical Findings
    - Research findings concerning Soil Based Organisms and the immune system

  • Spirulina can increase TH1 cytokines, improve macrophage activity, and improve cell mediated immunity and the overall effectiveness of the immune system in fighting infections. It also has antiviral properties.
    Research articles     & Clinical Findings
    - Research findings concerning Spirulina and the immune system

  • Pine Cone Extract Dr. Cheney believes it strengthens the TH1 part of the immune system, and enhances overall immune function. Research suggests that it has beneficial effects on the entire immune system.
    Research articles & Clinical Findings
    - Scientific papers

  • Lactobacillus acidophilus and probiotics can increase TH1 cytokines, reduce TNF-a, reduce cytokine IL-6, reduces CRP, improve mucousal integrity and intestinal integrity, and improve overall immune system functions. Its also helpful in autoimmunity. Bifidobacterium infantis 35624 is particularly good for ME patients.
    Click here to view Probiotics & Immunity

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines, molecular parts) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.

  • Fetal cell extracts (Live Cell Therapy) modulates the immune system and acts to normalise immune system functions
    Research articles & Clinical Findings
    - Clinical findings by medical doctors at famous Biocare Hospital in Mexico.

  • Gene-based therapies. According to recent genetic research by Dr. Kerr (1) there are 7 subgroups of ME and certain drugs may be beneficial for CFS subgroups. These are listed below:
    • APP gene. Drug: AAB-001. Subtypes 1, 2, 3, 4, 5, 6 and 7
    • CXCR4 gene. Drug: JM1300. Subtypes 5 and 6
    • FNTA gene. Drug: lonafarnib, tipifarnib. Subtypes 1, 2, 3, 5 and 6
    • IL6ST gene. Drug: tocilizumab. Subtypes 1, 2, 5, 6 and 7
    • TNF gene. Drug: golimumab, adalimumab, etanercept, certolizumab pegol, infliximab. Subtype 2

    Research articles & Clinical Findings
    1. Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr, B Burke, R Petty, J Gough, D Fear, D L Mattey, J S Axford, A G Dalgleish, D J Nutt. J. Clin. Pathol. 2008;61;730-739; originally published online 5 Dec 2007

  • Rectify Mitochondria dysfunctions. The mitochondria are essential to many immune system functions
    Research articles & Clinical Findings
    - Treatments for damaged Mitochondria anddefective Krebs cycle and ATP production

  • Sprouts, including broccoli sprouts, cabbage sprouts, radish sprouts, bean sprouts, lentil sprouts. Sprouts, in particular broccoli sprouts have a powerful effect on the immune system, they increase NK cell numbers and cytotoxicity, antibody response, cell mediated immunity and increase TH1 cytokines.
    Research articles & Clinical Findings
    - Researchers Find a Concentrated Anticancer Substance in Broccoli Sprouts, New York Times, 1997.
    - The influence of food cooking on the blood formula of man,  by. Paul Kouchakoff (Suisse), M.D. of the Institute of Clinical Chemistry, Lausanne, Switzerland.
    - Scientific papers

  • Normalise the HPA axis and endocrine system. This facilitates normal immune system function. HPA axis and Thyroid and Adrenal glands dysfunction tests (Found in high percentage of CFS cases)

  • Reducing Oxidative Stress on the Immune system
    Research articles & Clinical Findings
    - Vitamin E Deficiency: Miwa K, Fujita M: Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels 2010, 25:319-323.
    - Coenzyme Q10 Deficiency: Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E: Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 2009, 30:470-476
    - Glutathione Deficiency: Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.
    - Magnesium Deficiency: Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Neve J, De Leeuw I: Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 2000, 19:374-382.

Normalise Macrophages

Cell Mediated Immunity

  • Green Tea should not be taken by ME and CFS patients as it increases TH2 inflammatory cytokines

  • Beta 1,3 Glucan and foods containing this - Macrophage enhancer and improves cell mediated immunity
    Research articles & Clinical Findings
    -  Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Pages 110.- 112

  • Increasing and normalising TH1 cytokines and reducing TH2 cytokines may normalise cell mediated immunity
    • Chinese Skullcap (Scutellaria baicalensis) is the most powerful herb in this category
    • Combining the herbs Astragalus, Cordyceps, Rhodiola, Ashwagandha, Siberian Ginseng and Reishi mushrooms , according to renowned herbalist Stephen Buhner
    • Andrographis paniculata
    • Japanese Knotweed
    • Cats Claw
    • Ashwagandha
    • Turmeric

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.

  • BioPro Protein A - Thymus gland strenghtening. This is vital for all immune system subsets and functions.
    Research articles & Clinical Findings
    - Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Pages 113.- 115

  • Elagen is a powerful adaptogen and immune system tonic and enhancer. Many ME patients have benefitted from taking it.
    Research articles & Clinical Findings
    - http://www.elagen.com/research/
    - Patient Testimonials

  • Colostrum contains many immune system components, antibodies, immunoglobulins, cytokines, interferons, proline-rich polypeptides, transfer factors, amino acids, growth factors, lactoferrin and vitamins to normalise immune system functions. It is a very strong immune system modulator and improves NK cell numbers and functions, T cells and TH1 cytokines when used over several months and years. There are some good Colostrum products in the market. These include Colostrinin and Travelan which have been researched. Colostrum pills / powder / milk / cheeses can be bought online and offline. Natural Colostrum has been found to be very effective.
    Research articles & Clinical Findings
    - Listing of scientific research

  • Transfer factor products (antigen specific) - protein immuno-modulators extracted from the colostrum of immunologically stimulated animals can promote DTH and specific immunity to certain antigens (viruses, bacteria, mycoplasma, fungii, etc.). It can also improve NK cell functions and CD8 t cell functions. Priming and training the immune system to recognise and destroy viruses, bacteria, mycoplasma, fungii. Some good brands are available at http://transferfactor-4-life.com
    Cited: Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Page 71-74, 107-108, 407
    Research articles and Clinical Findings
    - Lessons from a pilot study of transfer factor in chronic fatigue syndrome. De Vinci C , Levine PH , Pizza G , Fudenberg HH , Orens P , Pearson G , Viza D . Biotherapy. 1996;9(1-3): 87-90. PMID: 8993764
    - Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports. Ablashi DV , Levine PH , De Vinci C , Whitman JE Jr , Pizza G , Viza D . Biotherapy. 1996;9(1-3):81-6. PMID: 8993763
    - Some Clinical Findings
    - Research findings concerning Transfer factor and the immune system
    - http://www.transferfactorresearch.com/autoimmune3.html
    - Myalgic Encephalomyelitis: Guidelines for Doctors John Richardson. Journal: J of Chronic Fatigue Syndrome, Vol. 10(1) 2002, pp. 65-80.

  • Treat Glutathione Decificency
     Glutathione is essential for many immune system functions. One can take Glutathione by injection and / or take Glutathione precursors. Glutathione precursors - undenatured whey protein, Immunocal / ImuPlus, N-acetyl cysteine (NAC), selenium, Alpha-lipoic acid, carnitine, cruciferous vegetables, vitamin c, glutamine, milk thistle, green barley grass, copper, manganese, zinc. Vitamin B-complex is important for Glutathione production. Also test your methylation cycle, and correct any problems or blocks ; Methylation cycle normalisation. This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment
    Research articles & Clinical Findings
    - Research findings concerning Glutathione and the immune system
    - Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.

  • Spirulina can increase TH1 cytokines, improve macrophage activity, and improve cell mediated immunity and the overall effectiveness of the immune system in fighting infections. It also has antiviral properties.
    Research articles     & Clinical Findings
    - Research findings concerning Spirulina and the immune system

  • Cordyceps improves overall immune system function
    Research articles & Clinical Findings
    - Research findings concerning Cordyceps and the immune system
    - Research concerning natural killer cells

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines, molecular parts) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.
  • Fetal cell extracts (Live Cell Therapy) modulates the immune system and acts to normalise immune system functions
    Research articles & Clinical Findings
    - Clinical findings by medical doctors at famous Biocare Hospital in Mexico.

  • Gene-based therapies. According to recent genetic research by Dr. Kerr (1) there are 7 subgroups of ME and certain drugs may be beneficial for CFS subgroups. These are listed below:
    • APP gene. Drug: AAB-001. Subtypes 1, 2, 3, 4, 5, 6 and 7
    • CXCR4 gene. Drug: JM1300. Subtypes 5 and 6
    • FNTA gene. Drug: lonafarnib, tipifarnib. Subtypes 1, 2, 3, 5 and 6
    • IL6ST gene. Drug: tocilizumab. Subtypes 1, 2, 5, 6 and 7
    • TNF gene. Drug: golimumab, adalimumab, etanercept, certolizumab pegol, infliximab. Subtype 2

    Research articles & Clinical Findings
    1. Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
    J R Kerr, B Burke, R Petty, J Gough, D Fear, D L Mattey, J S Axford, A G Dalgleish, D J Nutt. J. Clin. Pathol. 2008;61;730-739; originally published online 5 Dec 2007

  • Rectify Mitochondria dysfunctions. The mitochondria are essential to many immune system functions
    Research articles & Clinical Findings
    - Treatments for damaged Mitochondria anddefective Krebs cycle and ATP production

  • Acupuncture & Chinese Medicine
    The following acupuncture practitioners have had success treating ME and CFS patients
    Acupuncture: Maoshing Ni, California.

  • Sprouts, including broccoli sprouts, cabbage sprouts, radish sprouts, bean sprouts, lentil sprouts. Sprouts, in particular broccoli sprouts have a powerful effect on the immune system, they increase NK cell numbers and cytotoxicity, antibody response, cell mediated immunity and increase TH1 cytokines.
    Research articles & Clinical Findings
    - Researchers Find a Concentrated Anticancer Substance in Broccoli Sprouts, New York Times, 1997.
    - The influence of food cooking on the blood formula of man,  by. Paul Kouchakoff (Suisse), M.D. of the Institute of Clinical Chemistry, Lausanne, Switzerland.
    - Scientific papers

Lymphatic Drainage and Detoxification (Including Perrin Technique)
This is vitally important for all immune system functions. Most ME and CFS patients have a sluggish lymphatic system which leads to a build up of toxins and immune system dysfunctions.


Normalise IgG

  • Intravenous immunoglobulin to treat IgG subclass 1 and 3 deficiencies and other IgG deficiencies
    Research articles & Clinical Findings
    - "Interventions for the treatment and management of chronic fatigue syndrome: a systematic review". Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, Ramírez G (September 2001). JAMA 286 (11): 1360–8. doi:10.1001/jama.286.11.1360
    - Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome. Kerr JR , Cunniffe VS , Kelleher P , Bernstein RM , Bruce IN . Clin Infect Dis. 2003 May 1;36(9):e100-6. PMID: 12715326
    - Double-blind randomized controlled trial to assess the efficacy of intravenous gammaglobulin for the management of chronic fatigue syndrome in adolescents. Rowe KS . J Psychiatr Res. 1997 Jan-Feb;31(1):133-47. PMID: 9201655
    - A double-blind, placebo-controlled trial of intravenous immunoglobulin therapy in patients with chronic fatigue syndrome. Lloyd A , Hickie I , Wakefield D , Boughton C , Dwyer J . Am J Med. 1990 Nov;89(5):561-8. PMID: 2146875
    - I.M. injections.are most effective
    Myalgic Encephalomyelitis: Guidelines for Doctors John Richardson. Journal: J of Chronic Fatigue Syndrome, Vol. 10(1) 2002, pp. 65-80.

  • BioPro Protein A - Thymus gland strengthening. This is vital for all immune system subsets and functions.
    Research articles & Clinical Findings
    - Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Pages 113.- 115

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines, molecular parts) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.

Treatment for B cells and Autoimmune disorders (including Autoimmune marker mimcry)

Treatment of all chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections
Diagnose, treat and eliminate chronic viral, mycoplasmas, Lyme, bacteria, mold and parasite infections which both activate and weaken the immune system over time. This is essential in all cases of ME and CFS. Immune pathways and signalling systems can be disrupted by chronic infections. B cells are prone to infections which can instigate immune dysfunctions and autoimmune conditions.

  • Dr. Pender, a leading world authority on autoimmunity, who has researched autoimmune illnesses and viral infections and ME recommends the following:
  • Turmeric and it's active ingredient Curcumin has immune enhancing, anti-cancer, anti-inflammation and anti-viral properties. Comparison of Turmeric with Rituximab (mentioned above). Black pepper increases the absorption of Turmeric by 600% or more according to some studies.Research articles & Clinical Findings
    - Research findings concerning Turmeric and the immune system
  Turmeric / Curcumin Medical drug Rituximab
B cell Lymphoma

Combats it directly. May be of significant use in this illness according to scientific research.

Research and Clinical Findings
- Listing of completed research
- Developing curcumin into a viable therapeutic for lymphoma.

 Used in treatment of this illness. Causes B cell depletion.
B Cell CD20 marker

It may have indirect effects on B cells with CD20 marker

Research and Clinical Findings
- Listing of completed research

 It acts directly on B cells with CD20 marker
Cancer cell apoptosis

Can induce cancer cell apoptosis

Research and Clinical Findings
- Listing of completed research

 Can induce apoptosis of cancerous B cells with CD20 marker
CXCR4

Down regulation of CXCR4

Research and Clinical Findings
- http://www.ncbi.nlm.nih.gov/pubmed/17198877

 

Direct effects unknown. Has been used with anti-CXCR4 drugs to destroy cancer cells.

Research and Clinical Findings
- Listing of completed research
Various Cancers

Can combat several cancers according to scientific research. It may have applications in Cancer treatment.

Research and Clinical Findings
- Listing of completed research

B cell Lymphoma, Follicular Lymphoma, Hematological malignancy
Autoimmune diseases

Can combat some autoimmune diseases. It has applications in the treatment of some autoimmune diseases. Its main actions are regulation of cytokines, reduction of inflammation, normalisation of cell signalling, and normalisation of immune system function

Research and Clinical Findings
- Listing of completed research

 Rheumatoid arthritis, autoimmune hemolytic anemia, pure red cell aplasia, idiopathic thrombocytopenic purpura (ITP),  Evans syndrome, MS, vasculitis (for example Wegener's Granulomatosis), bullous skin disorders (for example pemphigus, pemphigoid—with very encouraging results of approximately 85% rapid recovery, in the treatment of pemphigus, according to a 2006 study), type 1 diabetes mellitus, Sjogren's syndrome, and Devic's disease,  and Graves' disease ophthalmopathy
Viruses, Bacteria

Has anti-viral and anti-bacterial properties

Research and Clinical Findings
- Listing of completed research

 No anti-viral and anti-bacterial properties
  • Vitamin D3 is important for cytotoxic T cells and for preventing / treating autoimmune illnesses.
  • IFN-b, also known as Betaseron. It enhances suppressor T cells, and helps stop autoimmune illness flare up and progression.
  • The Marshall Protocol is designed to modulate the immune system. According to it's author and it's many supporters, it can improve one's ability to utlilise Vitamin D and this directly impacts many immune system subsets and functions, it improves VDR, and it can reduce NFκB and TNF-a and inflammatory cytokines. It can also improve innate immunity and TH1 cytokines. These are major factors in ME and CFS. More information is presented here at :
    The Marshall Protocol web site and the following video lecture

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.
  • Colostrum contains many immune system components, antibodies, immunoglobulins, cytokines, interferons, proline-rich polypeptides, transfer factors, amino acids, growth factors, lactoferrin and vitamins to normalise immune system functions. It is a very strong immune system modulator and improves NK cell numbers and functions, T cells and TH1 cytokines when used over several months and years. There are some good Colostrum products in the market. These include Colostrinin and Travelan which have been researched. Colostrum pills / powder / milk / cheeses can be bought online and offline. Natural Colostrum has been found to be very effective.
    Research articles & Clinical Findings
    - Listing of scientific research
  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.
  • Folinic acid drugs / supplements or Leucovorin, a folinic acid derivative, in doses that ranged from 75mg to 100mg per day for several months was used to treat the B-cell abnormalities in ME patients in one scientific study. Some improvement was noted in patients.
    Research articles & Clinical Findings
    - Clinical activity of folinic acid in patients with chronic fatigue syndrome. Lundell K , Qazi S , Eddy L , Uckun FM. Arzneimittelforschung. 2006;56(6):399-404. PMID: 16889122
    - Clinical Activity of Folinic Acid in Patients with Chronic Fatigue Syndrome
  • Homeopathy
    • The Homeopathic remedies TOXEX spag., and apo-INFEKT spag., help fight pathogen infections, improve immune system functions and detoxify the body.
    • HEEL Inc. http://www.heelusa.com. uses special homeopathic remedies. 82% fully recovered after homeopathic treatment for viral infections and immune system weaknesses. Cited: Chronic Fatigue, Fibromyalgia, and Lyme Disease (Alternative Medicine Guides) (2nd Edition) '  by Burton Goldberg and Larry Trivieri. Page 75
    • A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. Weatherley-Jones E , Nicholl JP , Thomas KJ , Parry GJ , McKendrick MW , Green ST , Stanley PJ , Lynch SP . J Psychosom Res. 2004 Feb;56 (2):189-97. PMID: 15016577

 

Microglia Inhibitor drugs

These can inhibit and normalise over-activated Microglia

Drugs:

  • Naltrexone
  • Medical Marijuana and Cannabidiol
  • Tetracycline Antibiotics
  • Dextro-naltrexone
  • Minocycline
  • Ibudilast
  • Dextromethorphan
  • Rifampin
  • Propentofylline
  • Ceftriaxone
  • Glatiramer acetate
  • 3-hydroxymorphinan
  • Dilapimod
  • ATL313
  • BAY 60-6583
  • FP-1 Resolvin D1
  • Resolvin E1
 Supplements:

  • Uncaria rhynchophylla
  • Luteolin
  • Panax ginseng
  • Turmeric
  • Resveratrol
  • Gastrodia elata
  • Obovatol
  • Inflexin
  • Piper kadsura
  • Ganoderma lucidum (Reishi)
  • Berberine
  • Epimedium brevicornum
  • Isodon japonicas
  • Stephania tetrandra
  • Stinging nettle
  • Fisetin
  • Pycnogenol
  • Boswellia
  • Kratom



6. Nutritional, dietary changes, supplements, herbs and alternative medicine to normalise and strengthen the immune system

Avoidance of sugar and sweet foods. Several studies show that excessive sugar has a depressing effect on the immune system

Do you eat foods containing high levels of toxins and inflammation agents ?

    • hot dogs, sausages and cured meats which contain nitrosamines
    • sodas and fizzy drinks and diet drinks containing aspartame
    • foods containing MSG
    • foods containing GMO's
    • foods containing hydrogenated fats, trans fatty acids, and saturated fats. Margarine, canola oil, corn oil, peanut oil, soya oil, safflower oil
    • mucous forming foods such excessive potatoes, french fries (chips), cookies and sweets
    • refined sugars and foods containing refined sugars which can cause immune dysfunctions and inflammation. Stevia is healthier and safer.
    • processed and packaged foods containing additives and flavourings with E numbers
    • foods containing mercury – tuna, swordfish, shark
    • foods containing toxin residues from the land (arsenic in some rice)
    • table salt. Sea salt is healthier and safer.
    • chlorine in bathing / swimming water
    • flouride in drinking water
    • unfiltered drinking water

    all of these increase toxin load on the body, and inflammation, with adverse effects on the body, in particular the immune system, the DNA, the mitochondria, the endocrine system and the brain and nervous system. Eliminate these foods and drinks from the diet.

  • Organic Green Juices
    These green juices are very powerful and good for detoxification and boosting immune system functions. They also help protect DNA and mitochondria. You could juice combinations of the following in a blender or juicer :

    • celery
    • green barley grass
    • spirulina
    • green savoy cabbage
    • wheatgrass
    • coriander
    • chlorella
    • spirulina
    • kale
    • broccoli
    • watercress
    • brussels sprouts
    • spinach
    • dandelion
    • nettle
    • green peppers
    • parsley
    • broccoli sprouts, radish sprouts and cabbage sprouts
    • a few cloves or garlic or slices of onion
    • Seaweed - Kombu, Dulse, Kelp, Caragreen

These will detoxify the body, increase energy levels and improve immune system function. Avoid fruit shakes as the sugar can increase yeast infections and gut bacteria, reduce immunity and cause 'sugar blues' all of which can worsen ME.

  • Zinc, Selenium, Vitamins A, C and D are essential for normal immune system functions. Deficiencies in these undermine and weaken the immune system.
  • Sunlight in Summer and Spring and Light boxes in late Autumn and all Winter. Light can improve all immune system functions, while light deprivation can lead to a seriously weaknend and ineffective immune system
    Research articles Clinical Findings
    - Research findings concerning Sunlight and the immune system
  • Reducing Oxidative Stress on the Immune system
    Research articles & Clinical Findings
    - Vitamin E Deficiency: Miwa K, Fujita M: Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels 2010, 25:319-323.
    - Coenzyme Q10 Deficiency: Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E: Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 2009, 30:470-476
    - Glutathione Deficiency: Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.
    - Magnesium Deficiency: Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Neve J, De Leeuw I: Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 2000, 19:374-382.


7. Treatment for Vitamin D deficiency

  • If Vitamin D tests show a deficiency then supplementation with Vitamin D or medical drugs to do this is advised.


8. Treatment for Methylation Blockage
This cycle is essential to immune system function, anti-viral and anti-pathogen functions, mitochondria function and detoxification functions. It is being blocked in subsets of ME patients. See Section - Methylation Cycle and Glutathione depletion treatments as part of Immune system treatment

9. Treatment for adverse immune reactions to vaccines
Go to a medical doctor and Toxicologist, Immunologist and Neurologist to seek medical advice. Immune system modulators, anti-pathogen treatments, detox therapies, neurological and endocrine treatments and gene based treatments may be required. Homeopathy

    • The Homeopathic remedy Thuja spag. drops may be helpful.
    • A randomised, controlled, triple-blind trial of the efficacy of homeopathic treatment for chronic fatigue syndrome. Weatherley-Jones E , Nicholl JP , Thomas KJ , Parry GJ , McKendrick MW , Green ST , Stanley PJ , Lynch SP . J Psychosom Res. 2004 Feb;56 (2):189-97. PMID: 15016577


10. Other Immune Dysfunctions Treatments
Idiopathic CD4+ T lymphocytopenia

  • Immuno therapy
    This involves extracting and then re-training / re-programming various subsets of live immune cells (NK cells, Lymphocytes, T-cells, B-cells, Macrophages, Cytokines) and then injecting them back into the body. Studies show it is effective in some Cancers and chronic illnesses.
    Other therapies involve using bacteria / virus / antigens to stimulate immune response or destroy another pathogen / tumour. Some topical creams can powerfully stimulate immune system components and subsets of immune cells.
  • Re-designating old medical drugs for CFS Treatment
    CFIDS Association of America has got Biovista ( http://biovista.com ) in the USA to engage in research and data mining of thousands of medical drugs (including some which are currently out of use) and find matches between them and the symptoms, abnormalities and dysfunctions found in ME. They are compiling a list of these medical drugs. Safety guidelines, side effects, clinical reports and general efficacy and other factors will also be taken into account for each medical drug
  • Stress Reduction
    In addition to getting medical treatment for immune system, krebs cycle and methylation cycle dysfunctions, infections and other biological abnormalities and dysfunctions one should also get Stress Reduction treatment as all physical illnesses including Cancer, AIDS, ME, Multiple Sclerosis, Fibromyalgia, autoimmune illness, Cardiac related illnesses, advanced Diabetes, etc. causes great stress for patients. Click here for Stress Reduction treatment

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