Important
Note If tests show
that you suffer from any of these abnormalities / dysfunctions,
you can view the treatment options available and discuss them with
your own medical doctor or consultant. These
treatments can only be undertaken with the permission and
supervision of your own medical doctor
Dr. Paul Cheney
Redox treatment. "No one should take drugs if they do not need them for medical reasons and Klonopin is no different but a low energy state with low cardiac output such as CFS will devastate sleep and loss of redox control kills brain cells and Klonopin is strongly indicated in this circumstance, in my opinion, with 30 years of observing Klonopin use in CFS patients. Klonopin along with high dose, injectable hydroxyB-12 (30-60 mg per day) and low dose injectable Magnesium (0.1 cc) with Taurine (0.1 cc) and perhaps Inosine in some patients with serum Uric Acids below 6.0 have been a staple for treating CFS for decades. There is a reason for this success and all these drugs or supplements powerfully affect the redox state whose instability and poor buffering is the core of CFS and a major threat to brain cells, especially from CNS hypo-perfusion due to low cardiac output which is itself due to mitochondrial deficiency as published for CFS by Hollingsworth et al, Shungu et al, Nicholson et al and McLaren-Howard et al." Dr. Paul Cheney, Cheney Clinic, USA.
Researchers at the Whitehead Institute were trying to identify genetic defects that would lead to problems with mitochondrial functioning. They found that when they inactivated the gene ATPIF1, cells were protected from the damaging effects of mitochondrial defects. The enzyme acts to shut down the mitochondrial machinery and prevent it from depleting what little ATP remains. In mitochondrial disorders, cells falsely believe they are starved of oxygen and nutrients, and activates ATPIF1. When the scientists blocked ATPIF1 with a small molecule, they were able to keep the cell from falsely perceiving a problem, restoring the cell and the mouse to health.
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells. Cell Reports, 2014. doi: 10.1016/j.celrep.2014.02.046
Natural means of Repairing, Regenerating and Protecting the Mitochondria:
Cordyceps and Motherwort are the best herbs for protecting the mitochondria, especially during infections and recoveries from infections. They are specific for the mitochondria. They
stop oxidative and nitrosative stress injury to the brain and mitochondria.
Repair of Mitochondria membranes and cell membranes
For conditions of Hypoxia & mitochondria damage: succinate-containing drugs such as mexidole and proxipine. See research paper about this topic.
Resveratrol and drugs and supplements which increase SIRT-1 help repair and protect mitochondria. Also improves Sirtuins and their activities, SRT1720, SRT1460, SRT2104 may help increase SRT-1. Resveratrol can be found in red and black grapes and muscadine grapes, in Muscadine wine and Pinot Noir wine and in Japanese Knotweed and in Resveratrol supplements.
Japanese Knotweed has has high levels of resveratrol and been found to be very protective of the mitochondria in infectious illnesses and neurological and immune related illnesses
Astragalus can help protect mitochondria and improves Sirtuins involved in mitochondria and cell protection.
Cordyceps is very effective
Drugs and supplements which increaseLamin A help repair and protect mitochondria
Omega-3 oils - VegEPA, fish oils, flaxseed oil for cell membrane structure and integrity
Omega-6 oils - Evening Primrose oil
Lecithin provides vital lipids for cell membrane structure and integrity
Phosphatidyl Serine improves cell communications and signalling
Improve Mitochondria Function and ATP production and recycling
D-Ribose (the most important nutrient), Co-Q10, L-Carnitine, Propax NT Factor, Magnesium and Malic acid (or malate), Tyrosine, B-complex vitamins, Alpha Lipoic acidAND the following: Phenylalanine, Lysine, NADH, Manganese, Creatine, Iodine, Sulphur and sulphur rich foods, Virgin Coconut oil AND ensure there is adequate stomach acid and digestive enzymes in your stomach to absorb these vitamins, amino acids, foods and supplements.
Antioxidant vitamins and minerals - Vitamins A, C, E, B-complex, selenium, manganese zinc
Cordyceps is very effective
For conditions of Hypoxia & mitochondria damage: succinate-containing drugs such as mexidole and proxipine. See research paper about this topic
Nicotinamide, Vitamin B3 (Niacin) and Nicotinamide riboside and drugs and supplements which increase NAD+ help improve mitochondria function and also help repair and protect mitochondria. It also improves Sirtuins and their activities.
Resveratrol and drugs and supplements which increase SIRT-1 help repair and protect mitochondria. Also improves Sirtuins and their activities, SRT1720, SRT1460, SRT2104 may help increase SRT-1. Resveratrol can be found in red and black grapes and muscadine grapes, in Muscadine wine and Pinot Noir wine and in Japanese Knotweed and in Resveratrol supplements.
Japanese Knotweed has has high levels of resveratrol and been found to be very protective of the mitochondria in infectious illnesses and neurological and immune related illnesses
Astragalus can help protect mitochondria and improves Sirtuins involved in mitochondria and cell protection. .
Drugs and supplements which increaseLamin A help improve mitochondria functions
Mitochondria protection
Glutathione
Glutathione is essential for some mitochondria functions. Its depletion in ME patients is one of the main reasons for the many dysfunctions and abnormalities found in the illness. One can take Glutathione by injection and / or take Glutathione precursors. Glutathione precursors - undenatured whey protein, Immunocal / ImuPlus, N-acetyl cysteine (NAC), selenium, Alpha-lipoic acid, carnitine, cruciferous vegetables (broccoli, kale, cabbage, brussels sprouts, cauliflower),sulphur and sulphur rich foods, vitamin c, glutamine, milk thistle, green barley grass, copper, manganese, zinc. Vitamin B-complex AND ensure there is adequate stomach acid and digestive enzymes in your stomach to absorb these vitamins, amino acids, foods and supplements. And test your Methylation cycle, and correct any problems or blocks.
Hypoxia
For conditions of Hypoxia & mitochondria damage: succinate-containing drugs such as mexidole and proxipine. See research paper about this topic.
A combination of cordyceps, coptis rhizoma and sculletaria baicalensis can provide protection against oxidative and nitrosative stress and protect the body, organs, mitochondria and nervous system from damage (Buhner 2015)
Superoxide Dismustase inducers green barley grass, copper, manganese, zinc, Propax NT Factor, cordyceps, milk thistle AND ensure there is adequate stomach acid and digestive enzymes in your stomach to absorb these vitamins, amino acids, foods and supplements.
Resveratrol and drugs and supplements which increase SIRT-1 protect mitochondria. Also improves Sirtuins and their activities, SRT1720, SRT1460, SRT2104 may help increase SRT-1. Resveratrol can be found in red and black grapes and muscadine grapes, in Muscadine wine and Pinot Noir wine and in Japanese Knotweed and in Resveratrol supplements.
Japanese Knotweed has has high levels of resveratrol and been found to be very protective of the mitochondria in infectious illnesses and neurological and immune related illnesses
Antioxidant herbs and Foods
Cordyceps is very effective
A combination of cordyceps, coptis rhizoma and sculletaria baicalensis can provide protection against oxidative and nitrosative stress and protect the body, organs, mitochondria and nervous system from damage (Buhner 2015)
Spirulina has very powerful antioxidant effects
Anthocyanins and foods containing anthocyanins such as blueberries, cherries, blackberries, elderberries, bilberries, chokeberries (highest anthocyanin content), black raspberries.
Cocoa has very strong antioxidants
Sathyapalan T
,
Beckett S
,
Rigby AS
,
Mellor DD
,
Atkin SL
. High cocoa polyphenol rich
chocolate may reduce the burden of the symptoms in chronic fatigue syndrome. Nutr J.
2010 Nov 22;9:55. PMID: 21092175
Green tea
Sachdeva, A K; Kuhad, A; Chopra, K (2011). "Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome". Brain Research Bulletin 86 (3–4): 165–72. doi:10.1016/j.brainresbull.2011.06.007. PMID 21821105.
Sachdeva, A K; Kuhad, A; Tiwari, V; Arora, V; Chopra, K (2010). "Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome". Basic & Clinical Pharmacology & Toxicology 106 (6): 490–96. doi:10.1111/j.1742-7843.2009.00525.x. PMID 20088847.
Sachdeva, A K; Kuhad, A; Tiwari, V; Chopra, K (2009). "Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence". Behavioural Brain Research 205 (2): 414–20. doi:10.1016/j.bbr.2009.07.020. PMID 1964314.
Singal A
,
Kaur S
,
Tirkey N
,
Chopra K
. Green tea extract and catechin ameliorate chronic
fatigue-induced oxidative stress in mice.
J Med Food.
2005 Spring;8(1):47-52. PMID:
15857209
Turmeric is a strong antioxidant
Gupta A
,
Vij G
,
Sharma S
,
Tirkey N
,
Rishi P
,
Chopra K
. Curcumin, a polyphenolic
antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress
model.
Immunobiology.
2009;214(1):33-9. PMID: 19159825
See research listings for Turmeric and antioxidant on Google search engine
Olive leaf extract and olive leaf soups have strong antioxidant properties
Acai berries possess the strongest antioxidant properties of any food. They protect blood vessels, the heart, human organs and human tissues.
Nardostachys jatamansi
Lyle N
,
Gomes A
,
Sur T
,
Munshi S
,
Paul S
,
Chatterjee S
,
Bhattacharyya D
. The role of
antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the
chronic fatigue syndrome.
Behav Brain Res.
2009 Sep 14;202(2):285-90. PMID:
19375459
Ginkgo Biloba protects blood vessels and produces nitric oxide Scientific Research Ginko benefits
Chlorella is an antioxidant and stimulates natural antioxidant systems in the body.. Contains Chlorella Growth Factor (CGF), RNA and DNA all of which can be used by the body for human DNA repair and tissue regeneration. It also stimulates good bacteria growth in the bowel which is reduces toxin load and accompanying oxidative stresses.
Antioxidant Herbs - garlic, red onions, milk thistle, green vegetables, Radix Pseudostellariae, Astragalus, Naringin, Nardostachys jatamansi, Shilajit
N-acetyl cysteine
The most striking benefits in humans with a disease associated with chronically elevated O&NS, such as CFS, appear to occur following prolonged administration at between 2.8 and 4.2 g/day
Reid MB, Stokić DS, Koch SM, Khawli FA, Leis AA (1994) Nacetylcysteine inhibits muscle fatigue in humans. J Clin Invest 94(6):2468–2474 124.
Medved I, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X, McKenna MJ (2004) N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals. J Appl Physiol 97:1477–1485
McKenna MJ, Medved I, Goodman CA, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X (2006) N-acetylcysteine attenuates the decline in muscle Na+, K+−pump activity and delays fatigue during prolonged exercise in humans. J Physiol 576(Pt 1):279–288
Cobley JN, McGlory C, Morton JP, Close GL (2011) NAcetylcysteine’s attenuation of fatigue after repeated bouts of intermittent exercise: practical implications for tournament situations. Int J Sport Nutr Exerc Metab 21(6):451–61
. Lai ZW, Hanczko R, Bonilla E, Caza TN, Clair B, Bartos A, Miklossy G, Jimah J, Doherty E, Tily H, Francis L, Garcia R, Dawood M, Yu J, Ramos I, Coman I, Faraone SV, Phillips PE, Perl A (2012) N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebocontrolled trial. Arthritis Rheum 64(9):2937–46. doi:10.1002/art. 34502
Stanislaus R, Gilg AG, Singh AK, Singh I (2005) N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats. J Autoimmune Dis 2(1):4
Coenzyme Q10
Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E: Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 2009, 30:470-476.
Judy W. Southeastern Institute of Biomedical Research, Bradenton, Florida. Presentation to the 37th Annual Meeting, American College of Nutrition, October 13, 1996.
Maes M (2009) Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms. Curr Opin Psychiatry 22(1):75–83
Bentler SE
,
Hartz AJ
,
Kuhn EM
. Prospective observational study of treatments for
unexplained chronic fatigue. J Clin Psychiatry. 2005 May;66(5):625-32. PMID:
15889950
Werbach MR
. Nutritional strategies for treating chronic fatigue syndrome.
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2000 Apr;5(2):93-108. PMID: 10767667
Cordero MD, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, Bullón P, Sánchez-Alcazar JA. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition. 2012 Nov-Dec;28(11–12):1200–3. doi: 10.1016/j.nut. 2012.03.018. Epub 2012 Aug 14. PubMed PMID: 22898267. 247. Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, FernándezRodríguez A, Sánchez-Alcazar JA. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal. 2013 Oct 20;19(12):1356–61. doi: 0.1089/ ars.2013.5260. Epub 2013 Apr 6. PubMed PMID: 23458405.
Morris G, Anderson G, Berk M, Maes M (2013) Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. Mol Neurobiol 48(3):883– 903. doi:10.1007/s12035-013-8477-8
9. Gökbel H, Gül I, Belviranl M, Okudan N (2010) The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 24(1):97–102 250. Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R (2008) Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr 5:8
Carnitine Carnitine is essential for mitochondria health and function.
Kuratsune H, Yamaguti K, Lindh G, Evengard B, Takahashi M, Machii T, Matsumura K, Takaishi J, Kawata S, Langstrom B, Kanakura Y, Kitani T, Watanabe Y (1998), "Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases", Int J Mol Med. Jul;2(1):51-6
Research papers of Professor Peter Behan, The Institute of Neurological Sciences,
University of Glasgow, Scotland)
Kuratsune H, Yamaguti K, Takahashi M, e.a. (1994), "Acylcarnitine deficiency in chronic fatigue syndrome", Clin Infect Dis, Jan;18 Suppl 1:S62-7
Inazu M, Matsumiya T (June 2008). "[Physiological functions of carnitine and carnitine transporters in the central nervous system]". Nihon Shinkei Seishin Yakurigaku Zasshi (in Japanese) 28 (3): 113–20. PMID18646596
Malaguarnera M, Gargante MP, Cristaldi E et al. (2008). "Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue". Arch Gerontol Geriatr 46 (2): 181–90. doi:10.1016/j.archger.2007.03.012
De Simone C, Famularo G, Tzantzoglou S, et al. Carnitine depletion in peripheral blood mononuclear cells from patients with AIDS: effect of oral L-carnitine. AIDS 1994;8:655-660
Jones, M. G., Goodwin, C. S., Amjad, S. & Chalmers, R. A. Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome. Clinica chimica acta; international journal of clinical chemistry 360, 173–7 (2005).
Plioplys AV, Plioplys S. Serum levels of carnitine in chronic fatigue syndrome: clinical correlates. Neuropsychobiology 1995;32:132-138
Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsychobiology. 1997;35:16-23.
Famularo G, De Simone C. A new era for carnitine? Immunol Today 1995;16:211-2133
Reuter, S. E. & Evans, A. M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. Journal of internal medicine 270, 76–84 (2011).
Vermeulen RC
,
Scholte HR
. Exploratory open label, randomized study of acetyl- and
propionylcarnitine in chronic fatigue syndrome.
Psychosom Med.
2004 Mar-Apr;66(2):
276-82. PMID: 15039515
D-Ribose
Teitelbaum, J. E., Johnson, C. & St Cyr, J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. Journal of alternative and complementary medicine (New York, N.Y.) 12, 857–62 (2006).
Teitelbaum, J., Jandrain, J. & McGrew, R. Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose– An Open-label, Multicenter Study. The open pain journal 32–37 (2012).
NADH
Forsyth LM, Preuss HG, MacDowell AL, Chiazze L, Birkmayer GD, Bellanti JA (February 1999). "Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome". Ann. Allergy Asthma Immunol. 82 (2): 185–91.
Santaella, M. L., Font, I. & Disdier, O. M. Comparison of oral nicotinamide adenine dinucleotide (NADH) versus conventional therapy for chronic fatigue syndrome. Puerto Rico health sciences journal 23, 89–93 (2004).
Alegre, J. et al. Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome. Revista clínica española 210, 284–8 (2010).
Glutathione
Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ: Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012, 25:1073-1087.
Magnesium
Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Neve J, De Leeuw I: Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 2000, 19:374-382.
Howard JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome. Letter. Lancet 1992;340:426.27. .
Chambers D, Bagnall AM, Hempel S, Forbes C (October 2006). "Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review". J R Soc Med 99 (10): 506–20. doi:10.1258/jrsm.99.10.506. PMC1592057
Cox IM, Campbell MJ, Dowson D (1991). "Red blood cell magnesium and chronic fatigue syndrome". Lancet 337 (8744): 757–60. doi:10.1016/0140-6736(91)91371-Z
Grant JE, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996;96:383-386
Jessop, Carol – reported in the Fibromyalgia Network Newsletter compendium #2, October 1990-January 1992. 53.
Moorkens G, Manuel Y, Keenoy B, et al. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res 1997;10:329-337.
Werbach MR
. Nutritional strategies for treating chronic fatigue syndrome.
Altern Med
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2000 Apr;5(2):93-108. PMID: 10767667
Takahashi H
,
Imai K
,
Katanuma A
,
Sugaya T
,
Hisano K
,
Motoya S
,
Aoki S
,
Sugiyama T
,
Yachi A
. A case of chronic fatigue syndrome who showed a beneficial effect by
intravenous administration of magnesium sulphate.
Arerugi.
1992 Nov;41(11):1605-10.
PMID: 1492795
Omega-3 oils and Zinc
Dr. Basant Puri has found that VegEPA can reduce lesions on the brain and improve brain function and structure in ME patients. Findings outlined in Dr. Puri's book Chronic Fatigue Syndrome: a natural way to treat M.E.
Puri BK
,
Holmes J
,
Hamilton G
. Eicosapentaenoic acid-rich essential fatty acid
supplementation in chronic fatigue syndrome associated with symptom remission and
structural brain changes.
Int J Clin Pract. 2004 Mar;58(3):297-9.
PMID: 15117099
Puri BK
. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome.
Prostaglandins Leukot Essent Fatty Acids.
2004 Apr;70(4):399-401. PMID: 15041033
Maes M, Mihaylova I, Leunis JC: In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett 2005, 26:745-751.
Chambers D, Bagnall AM, Hempel S, Forbes C (October 2006). "Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review". J R Soc Med 99 (10): 506–20. doi:10.1258/jrsm.99.10.506. PMC1592057
Behan PO, Behan WM, Horrobin D (1990). "Effect of high doses of essential fatty acids on the postviral fatigue syndrome". Acta Neurol. Scand. 82 (3): 209–16. doi:10.1111/j.1600-0404.1990.tb04490.x
Gray JB, Martinovic AM. Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome. Med Hypotheses 1994;43:31-42
Kury PG, Ramwell PW, McConnell HM. The effect of prostaglandin E1 and E2 on the human erythrocyte as monitored by spin labels. Biochem Biophys Res Commun 1974;56:478-483
Werbach MR
. Nutritional strategies for treating chronic fatigue syndrome.
Altern Med
Rev.
2000 Apr;5(2):93-108. PMID: 10767667
Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.Maes M, Mihaylova I, De Ruyter M. J Affect Disord. 2006 Feb;90(2-3):141-7. Epub 2005 Dec 9.
Jessop, Carol – reported in the Fibromyalgia Network Newsletter compendium #2, October 1990-January 1992. 53.
Werbach MR
. Nutritional strategies for treating chronic fatigue syndrome.
Altern Med
Rev.
2000 Apr;5(2):93-108. PMID: 10767667
High doses of Vitamin C (to protect mitochondria)
" STATEMENT ON CFIDS Robert F. Cathcart, M. D. In retrospect, I saw the first patients with CFIDS in Incline Village about 1978. The epidemic officially started sometime in 1983 in Incline Village. I left Incline Village January 1, 1980 but continued to treat patients for chronic fatigue. My treatment was mainly with massive doses of vitamin C but it also included many other nutrients. The rationale has been that CFIDS is a free radical disease involving damaged mitochondria.
My suspicion that chronic fatigue was a free radical disease involving mitochondria was because of the beneficial effect of massive doses of vitamin C. I was using the massive doses of vitamin C not for the vitamin C but for the electrons carried by the vitamin C. Ordinarily, when a vitamin C molecule gives up its two extra electrons to scavenge two free radicals, the vitamin C is refueled with two more electrons from the mitochondria. When the mitochondria are damaged and cannot provide the electrons then the spent vitamin C is rapidly irreversibly lost. By giving massive doses of C, this loss is prevented, and the continuing supply of fresh vitamin C substitutes for the inability of the mitochondria to provide the electrons to refuel the spent vitamin C (dehydroascorbate.)
Not incidentally, a major function of the mitochondria is to provide electrons in the form of ATP to the muscles. Without sufficient ATP to fuel the muscles, fatigue results. The mitochondria are damaged by either viruses, bacteria (sometimes cell wall deficient bacteria, L-forms), yeast toxins, sensitivity to chemicals (including some drugs), allergic reactions, etc. Probably, it usually involves two or more of the above. The damaged mitochondria become the major source of free radicals. A free radical cascade results. Free radicals from a damaged mitochondria damage adjacent mitochondria and cause them to produce more free radicals. A domino effect results. Because all this up-regulates the immune system, various autoimmune phenomena frequently result which may include aching in muscles, trigger points, etc. (fibromyalgia). The oral doses of ascorbic acid necessary to substitute for the inability of the mitochondria to supply electrons to refuel the free radical scavengers are at least bowel tolerance doses (see my other papers on this website.) Many patients have found that intravenous ascorbate is effective and necessary from time to time. The main problem has been with insurance not paying for intravenous ascorbate. While there is some expense involved with intravenous ascorbate it has been more effective than that drug costing $15,000 to $19,000 a year. $15,000 of intravenous ascorbate would probably have a chronic fatigue patient dancing a jig.
Ascorbate is not usually a cure for CFIDS but in patients who tolerate massive doses orally (almost everyone tolerates IV ascorbate), it ameliorates the disease better than other treatments. This more effective amelioration is because replacing the mitochondria function of providing the electrons for free radical scavenging gets more at the basic pathological processes in the disease and it helps protect the mitochondria so they can try to repair themselves. The disinterest in the use of ascorbate is hard to understand and it has contributed to not discovering basic causes of the disease. I doubt that short of killing a virus that may be the cause of many cases that there will be found a more effective method of ameliorating the symptoms of the disease. "
Vitamin E
Miwa K, Fujita M: Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels 2010, 25:319-323.
Vitamin B complex
Werbach MR
. Nutritional strategies for treating chronic fatigue syndrome.
Altern Med
Rev.
2000 Apr;5(2):93-108. PMID: 10767667
Fujii Y, Takahashi S, Toyooka H (2013) Protection from diaphragmatic fatigue by nitric oxide synthase inhibitor in dogs. Anaesth Intensive Care. 1999 Feb;27(1):45–8. Retraction in: Gibbs N. Anaesth Intensive Care 41(2):275 128.
Grassi B, Hogan MC, Kelley KM, Howlett RA, Gladden LB (2005) Effects of nitric oxide synthase inhibition by l-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol 568(Pt 3): 1021–33
Clean drinking water every day. Use a water filter which removes fluoride, organophosphates, chemicals, heavy metals, toxins, sediment, bacteria, viruses and other pathogens
Do you eat foods containing high levels of toxinsand inflammation agents?
hot dogs, sausages and cured meats which contain nitrosamines
sodas and fizzy drinks and diet drinks containing aspartame
mucous forming foods such excessive potatoes, french fries (chips), cookies and sweets
refined sugars and foods containing refined sugars which can cause immune dysfunctions and inflammation. Stevia is healthier and safer.
processed and packaged foods containing additives and flavourings with E numbers
foods containing mercury – tuna, swordfish, shark
foods containing toxin residues from the land (arsenic in some rice)
table salt. Sea salt is healthier and safer.
chlorine in bathing / swimming water
flouride in drinking water
unfiltered drinking water
all of these increase toxin load on the body, and inflammation, with adverse effects on the body, in particular the immune system, the DNA, the mitochondria, the endocrine system and the brain and nervous system. Eliminate these foods and drinks from the diet.
Water intake: 4-5 pints of clean filtered water every day to improve nutrient uptake at cellular level and excretion of toxins
Organic Green Juices
These green juices
are very powerful and good for detoxification and boosting immune system functions. They also help protect DNA and mitochondria. You could juice combinations of the following in a blender or juicer :
celery
green barley grass
spirulina
green savoy cabbage
wheatgrass
coriander
chlorella
kale
broccoli
watercress
brussels sprouts
spinach
green peppers
parsley
broccoli sprouts, radish sprouts and cabbage sprouts
a few cloves or garlic or slices of onion
These will detoxify the body, increase energy levels and improve immune system function. Avoid fruit shakes as the sugar can increase yeast infections and gut bacteria, reduce immunity and cause 'sugar blues' all of which can worsen ME.
Causes of oxidative stress and free radicals. Free radicals and oxidative stress can be increased in a toxic body, and in a body whose immune system is chronically activated through infection, inflammattion and allergies. Do additional tests for bowel toxicity and heavy metal and organophosphate toxicity. If toxicity is detected, then treat it.
If there are Mitochondria defects then ask your medical doctor to prescribe relevant medicine. The book Reviving The Broken Marionette: Treatments For Cfs/Me And Fibromyalgia by Maija Haavisto, has some very good advice about medical drug treatments for the many abnormalities and dysfunctions found in ME patients.
After analysing Essential Metabolic Analysis, by Spectracell Laboratory and identifying the deficiencies in vitamins, minerals, amino acids and antixoxidants at cellular level, discuss this problem with your medical doctor and clinical nuritionist and get supplements and / or injections and relevant foods to restore these to normal at cellular level.
Dr.
Paul Cheney's recommendations (Dr. Paul Cheney has successfully
treated hundreds of CFS patients in the USA) For mitochondria function and immune system - Undenatured
whey protein, Reduced L-Glutathione, B-12 Injections, Kutapressin.
Re-designating old medical drugs for CFS Treatment CFIDS Association of America has got Biovista ( http://biovista.com ) in the USA to engage in research and data mining of thousands of medical drugs (including some which are currently out of use) and find matches between them and the symptoms, abnormalities and dysfunctions found in ME. They are compiling a list of these medical drugs. Safety guidelines, side effects, clinical reports and general efficacy and other factors will also be taken into account for each medical drug
Stress Reduction
In addition to getting medical treatment for immune system, krebs cycle and methylation cycle dysfunctions, infections and other biological abnormalities and dysfunctions one should also get Stress Reduction treatment as all physical illnesses including Cancer, AIDS, ME, Multiple Sclerosis, Fibromyalgia, autoimmune illness, Cardiac related illnesses, advanced Diabetes, etc. causes great stress for patients. Click here for Stress Reduction treatment
by Dr. Sarah Myhill