• Anticardiolipin Antibodies in the Sera of Patients with Diagnosed Chronic Fatigue Syndrome Yoshitsugi Hokama, Cara Empey Campora, Cynthia Hara, Tina Kuribayashi, Diana Le Huynh, and Kenichi Yabusaki. Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Maˆnoa, Honolulu, Hawaii. Journal of Clinical Laboratory Analysis 23 : 210–212 (2009).

• Hokama Y, Empey-Campora C, Hara C, et al. Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS) chronic ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins. J Clin Lab Anal 2008;22:99–105.

• Knox, K., et al. Systemic Leukotropic Herpesvirus Infections and Autoantibodies in Patients with Myalgic Encephalomyelitis – Chronic Fatigue Syndrome. 7th International Conference on HHV-6 and 7. March 1, 2011. Reston, VA.

• 'Acute Phase Phospholipids Related to the Cardiolipin of Mitochondria in the Sera of Patients With Chronic Fatigue Syndrome (CFS), Chronic Ciguatera Fish Poisoning (CCFP), and Other Diseases Attributed to Chemicals, Gulf War, and Marine Toxins' Yoshitsugi Hokama et al. Journal of Clinical Laboratory Analysis 22:99–105 (2008)

• Important scientific findings in the book Osler's Web: Inside the Labyrinth of the Chronic Fatigue Syndrome Epidemic by Hillary Johnson where medical doctors in the USA found an unusually high number of B cell lymphomas in ME / CFS patients. Special scientific tests showed that these B-cell Lymphomas in ME / CFS patients were unusual types, not seen before. The researchers also found B-cell deficiency in all patients, and a positive result on the kappa/lambda assay for a majority of these patients. This is significant as kappa/lambda light chains are the result of abnormalities within the bone marrow B-cell lineage. This has direct on B-cells and overall immunity, and susceptibility to Cancers. Recent scientific studies show that the incidence rate of non-Hodgkin's lymphoma is 0.02% in the United States, yet nearly 5% of CFS patients develop the disease. This is a significant risk factor.

• Dr. Uckun et al , recently published a paper  'Clinical Activity of Folinic Acid in Patients with Chronic Fatigue Syndrome'   In this article, the researchers found that 94% of the CFS patients had a B-cell immunodeficiency with a marked depletion of their CD19+IgM+ mature B-lymphocyte population.  The CD19+IgM+ cells ranged from a low of 0.5% to a high of 53%.  These researchers concluded that there was "a high incidence of severe B-cell immunodeficiency" in CFS patients. This correlates to clinical and scientific findings in the book Osler's Web mentioned above.

• HHV-6a  virus which has been consistently found in high pecentages of ME / CFS patients has been found to be associated with Hodgkin's lymphoma, acute lymphocytic leukemia, African Burkitts lymphoma, and sarcoidosis, as well as AIDS and Chronic Fatigue Syndrome. Lusso, P. et al.; "In Vitro Cellular Tropism of Human B-Lymphotropic Virus(Human Herpesvirus-6)"; Journal of Experimental Medicine 167:1659, May 1988.

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