• Many patients with CFIDS symptoms have been found to be positive by PCR, using a gene tracking mechanism. Dr. Garth Nicolson PhD
  "In recent published studies from our laboratory, most CFS and FMS patients had multiple mycoplasmal infections. The number of different mycoplasmal species in these patients increased with the number of years the patients were sick and with the severity of their illness," says Dr. Nicolson

• In Belgian studies, 68.7% of CFS patients were infected with mycoplasma, with a predominance od M.hominis. Mycoplasma can lead to calpain cleavage. Mycoplasma can invade all tissues such as monocytes, muscle cells, etc..
  Professor Kenny De Meirleir (Brussles), research paper submitted to the AACFS 5th International Research, Clinical and Patient Conference, 2001

• Nicolson et al showed that multiple co-infections (Mycoplasma, Chlamydia, HHV-6) in blood of chronic fatigue syndrome patients are associated with signs and symptoms: “Differences in bacterial and/or viral infections in (ME)CFS patients compared to controls were significant…The results indicate that a large subset of (ME)CFS patients show evidence of bacterial and/or viral infection(s), and these infections may contribute to the severity of signs and symptoms found in these patients” (Nicolson GL et al. APMIS 2003:111(5):557-566).

• Gulf War Syndrome and other illnesses have been researched by Dr. Garth Nicolson and other scientists. Dr. Nicolson has publications, reports and made sworn testimonies to Presidential Commissions and committees of the U. S. Congress. He exposed illegal experiments on US military personnel, exposures to dangerous toxins and tests on people in American nursing homes, prisons and hospitals.
  http://www.projectdaylily.com

• Research by Donald Scott
  MYCOPLASMA : The Linking Pathogen in Neurosystemic Diseases
  The linking pathogen in CFS, Parkinsons, MS, Alzheimers disease.
  Salem News article on Mycoplasmas and neurological illnesses

• "What is unusual and what probably is not even appreciated by many specialists in infectious diseases, is that these mycoplasma organisms have the ability to infect white blood cells on a long term basis, and may even remain in such cells indefinitely. The consequence of this is that the energy (in the form of Adenosine Tri-Phosphate, or ATP) produced by these cells and by other cells (including those of the brain, muscles and joints) that become infected, is 'siphoned off' by these pathogens. Thus, this very important energy currency (ATP) is scavenged by such mycoplasma organisms, which in turn probably contributes to the excessive fatiguability and dysfunction of these infections, and if it should occur on a chronic basis, would have many other secondary negative effects throughout the body due to the loss of the ATP energy necessary to drive the large number of biochemical ATP-dependent systems required for normal cellular function, including those of the brain itself."
  Dr. John Whiting, Dr Philip Stowell and Dr Gary Deed Newcastle University, Australia.

• Nasralla M et al. Eur J Clin Microbiol Infect Dis 1999; 18: 859

• Vojdani A et al. FEMS Immunol Med Microbiol 1998; 22: 355

• Choppa PC et al. Mol Cell Probes 1998; 12: 301

• Nasralla M, Haier J, Nicolson GL: Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome. Eur J Clin Microbiol Infect Dis 1999;18:859-65.

• Polymerase chain reaction (PCR) techniques have established a connection between possible mycoplasmal blood infections and CFS in 50 to 60% of patients.

• Nasralla M et al. Eur J Clin Microbiol Infect Dis 1999; 18: 859

• Vojdani A et al. FEMS Immunol Med Microbiol 1998; 22: 355

• Choppa PC et al. Mol Cell Probes 1998; 12: 301

• "68.7% patients were infected with mycoplasma in Belgian studies with a predominance of M.hominis. Mycoplasma can lead to calpain cleavage. Mycoplasma can invade all tissues such as monocytes, muscle cells etc. " Professor Kenny De Meirleir (Brussles), research paper submitted to the AACFS 5th International Research, Clinical and Patient Conference, 2001

• "Kenny de Meirleir and his group looked at the association between mycoplasmae and the 2-5A/RNaseL pathway in CFS. The hypothesis was that there maybe a co-morbid physiopathological mechanism between Mycoplasma infection and the deregulation of the pathway. 182 mainly female patients, free of antibiotic treatment were enrolled. There was significant correlation. He showed that mycoplasmae are active in stimulating some components of the immune system. They can act as polyclonal T cell and B cell activators. Monocytes produce elastase, which can cleave 80kDa RNaseL thus causing deregulation of the antiviral pathway. It has been suggested that LMW RNaseL may reduce Th1 activity, which implicates susceptibility to infections and a suppressed ability to eliminate intracellular antigens."
  Research paper presented by Kenny de Meirleir (Brussels, Belgium) to The Sydney ME / CFS Clinical and Scientific Conference, December 2001

• "Pathophysiological mechanisms and CFS were discussed by Kenny de Meirleir (Brussels, Belgium). He described this condition as having no single aetiologic agent, but there are a number of predisposing factors leading to abnormalities in the immune system. Viral reactivation and opportunistic infections increase. Resultant ankyrin fragments from pathologically cleaved RNaseL interact with ABC transporters, which become dysfunctional, leading to many of the symptoms of CFS. This is described as an acquired channelopathy. 206 CFS patients were studied and 70% were found to be Mycoplasma positive, and these patients had significantly more cleavage fragments of RNaseL.
  He also mentioned the Bijlmer incident, when following this plane crash, 67% were found to be infected with Mycoplasma, and suffered CFS-like symptoms."
  Research findings presented by Professor Kenny de Meirleir (Belgium) to The Sydney ME / CFS Clinical and Scientific Conference, December 2001

• "Pascale de Becker had a further poster providing evidence for a channelopathy in a subset of CFS patients, probably induced by the deregulated RNaseL antiviral pathway.
  She had another poster showing the prevalence of Mycoplasma in Belgian CFS patients. This organism was found in 68.7% of a group of 272 patients. M.hominis was the most frequently observed followed by M.pneumoniae, and 17.3% had multiple infections."
  Research findings presented by Pascale de Becker (Brussels, Belgium) to The Sydney ME / CFS Clinical and Scientific Conference, December 2001

• "A plane crash in the area of Bijlmer resulted in a number of local people experiencing health problems. E Van Hoof (Brussels) presented data suggesting these complaints were similar to CFS and Gulf War illness. 67% were found to be infected with mycoplasma."
  E Van Hoof (Brussels), research paper submitted to the AACFS 5th International Research, Clinical and Patient Conference, 2001

• "Pathogenic Mycoplasma", US Patent No. 5,242,820, issued September 7, 1993. Dr Lo is listed as the "Inventor" and the American Registry of Pathology, Washington, DC, is listed as the "Assignee".
  

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