Sub-groups within ME
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Differentially expressed genes in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) patients reveal seven subtypes with distinct clinical phenotypes. Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. Journal of Infectious Diseases 2008;197:1171-84.
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Seven genomic subtypes of Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME): a detailed analysis of gene networks and clinical phenotypes. Kerr JR, Burke B, Petty R, Gough J, Fear D, Mattey DL, Axford JS, Dalgleish AG, Nutt DJ. Journal of Clinical Pathology 2008;61:730-9
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Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. Zhang L, Gough J, Christmas D, Mattey DL, Richards SC, Main J, Enlander D, Honeybourne D, Ayres JG, Nutt DJ, Kerr JR.. J Clin Pathol. 2010 Feb;63(2):156-64.
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Differentially expressed genes in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) patients reveal seven subtypes with distinct clinical phenotypes. Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. Journal of Infectious Diseases 2008;197:1171-84.
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"P de Becker (Brussels) produced results of a factor analysis
which determined 4 symptom groupings: general, cognitive,
musculoskeletal and mood changes/psychiatric factors. The first 3
group scores fitted with both Holmes and Fukuda defined CFS patients,
while the mood change/psychiatric factor score was not an important
factor in determination of CFS. The musculoskeletal factor determined
exercise ability."
P de Becker (Brussels), research paper submitted to the AACFS 5th
International Research, Clinical and Patient Conference, 2001
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