Substance P is elevated in
ME patients
- Research
by Dr. Jay Goldstein shows that substance P is elevated in ME
patients. Substance P is associated with inflammation, pain and brain
disorders. This elevation of Substance P is very significant as it
would explain the pains, inflammation, allergies, confusion and
"brain fog" commonly found in ME/ CFS patients. Taken
from Dr. Goldsteins book - http://home.vicnet.net.au/~mecfs/general/goldstein1.html
"High levels of Substance P have repeatedly been found in CFS
and may be responsible for the inappropriate post-exertional
fatigue."
"Gateing information is transmitted to your thalamus by a
neurotransmitter called glutamate. Glutamate levels are abnormal in
the CFS/FMS brain. Norepinephrine, a neurotransmitter that
increases signal to noise ratio is low in the CFS/FMS brain, whereas substance
P, a neurotransmitter which lowers signal to noise ratio is
increased in the CFS/FMS brain. (Injection of substance P into the
cerebrospinal fluid of healthy volunteers gives them diffuse body pain
similar to that seen in FMS.)"
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