Scientific and Medical Evidence - Listing of Research conducted worldwide section :
Substance P is elevated in ME patients
Serious Brain and nervous system abnormalities
Spinal Fluids & Proteomic Markers
ME Primer for Healthcare Professionals: based on Myalgic encephalomyelitis: International Consensus Criteria, 2012
Increased oxidative stress .
Muscle damage

Pain is the most consistent finding in ME and CFS patients. The severity of pain and the location of pain differs between subgroups of patients. Pain needs to be measured and assessed in each patient in order to designate them to subgroups and appropriate treatments.

Tests

• Specific Tests and Biomarkers mentioned in ME Primer for Healthcare Professionals: based on Myalgic encephalomyelitis: International Consensus Criteria, 2012

• Small Fibre Neuropathy (SFN)
  This has been found in ME / CFS and Fibromyalgia. It is believed to be the main contributing factor to severe pain in ME / CFS and Fibromyalgia patients. A neurologist can carry out tests for Small Fibre Neuropathy (SFN). Dr. Gupta advises that physicians carry out a skin biopsy.
  
  
• Activated Microglia
  This has been found in several studies. This contributes to pain. Test for activated Microglia in the brain and nervous system.

• Neurological Inflammation Tests

• Brain Scans - Hypo-perfusion and Lesions on the brain, Neuroinflammation, EEG markers, NMDA activity

• Intestinal  toxic damage with effects on the immune system, mitochondria, glands and nervous system (Found in high percentage of ME cases)

• Dr. Byron Hyde recommends the following for doctors:
  
  Pain Syndromes:
  The pain syndromes associated with the acute and chronic phases of M.E. may include
  (a) severe headaches of a type never previously experienced,
  (b) often associated with neck rigidity and occipital pain,
  (c) retro-orbital eye pain, (d) migratory muscle and arthralgia pain,
  (e) cutaneous hypersensitivity and
  (f) fibromyalgia type pain.
  These pain syndromes tend to decrease over time.